The following video segment is part of a full interview, in which The Motley Fool's Brendan Byrnes sits down with Irwin Simon, the founder and CEO of Hain Celestial (NASDAQ: HAIN ) , to take a closer look at the better-for-you food revolution. In this segment, they discuss how�being founder-led has resulted in company growth.
The Motley Fool's chief investment officer has selected his No. 1 stock for the next year. Find out which stock it is in the brand-new free report: "The Motley Fool's Top Stock for 2013." Just click here to access the report and find out the name of this under-the-radar company.
Brendan Byrnes: Let's talk big picture, and one of the things that we usually like to see at The Fool is founder-led companies. We see that with Amazon, Whole Foods, Google with Larry Page coming back, but what are some advantages do you think of a founder running the company that he started and what are some maybe disadvantages, if you think there are any?
Top 10 Stocks To Buy Right Now: New Jersey Resources Corp (NJR)
New Jersey Resources Corporation (NJR), incorporated in 1981, is an energy services holding company providing retail and wholesale energy services to customers in states from the Gulf Coast and Mid-Continent regions to the Appalachian and Northeast regions, the West Coast and Canada. NJR's subsidiaries and businesses include New Jersey Natural Gas (NJNG), NJR Clean Energy Ventures (NJRCEV), NJR Energy Services (NJRES) and NJR Energy Holdings Corporation (NJREH). NJNG is a local natural gas distribution company, which provides regulated retail natural gas service to approximately 500,100 residential and commercial customers in central and northern New Jersey and participates in the off-system sales and capacity release markets. NJR Clean Energy Ventures (NJRCEV) comprises the Company's Clean Energy Ventures segment and reports the results of operations and assets related to the Company's capital investments in renewable energy projects, including commercial and residential solar projects, as well as on-shore wind projects through a 19.9% interest in OwnEnergy. NJRES maintains and transacts around a portfolio of physical assets consisting of natural gas storage and transportation contracts. NJRES also provides wholesale energy management services to other energy companies and natural gas producers. NJRES comprises the Company's Energy Services segment. NJREH invests in energy-related ventures through its subsidiaries, NJNR Pipeline Company (Pipeline), which holds the Company's 5.53% ownership interest in Iroquois Gas Transmission L.P. (Iroquois) and NJR Steckman Ridge Storage Company, which holds the Company's 50% combined interest in Steckman Ridge GP, LLC and Steckman Ridge, LP (collectively, Steckman Ridge), a natural gas storage facility. Iroquois and Steckman Ridge comprise the Company's Energy Holdings segment.
NJR has retail and other operations (Retail and Other). NJR Retail Holdings (Retail Holdings) is consolidates the Company's unregulated retail operations. Retail Holdings consi! sts of wholly owned subsidiaries, including NJR Home Services (NJRHS), a company which provides heating, ventilation and cooling (HVAC) service repair and contract services to approximately 134,900 customers, as well as solar installation projects; Commercial Realty & Resources (CR&R), a company that holds and develops commercial real estate holds and develops commercial real estate, and NJR Plumbing Services (NJRPS), a company that provides plumbing repair and installation services.
NJR Energy Investments (NJREI) is an unregulated affiliate, which consolidates the Company's unregulated energy-related investments. NJREI includes the wholly owned subsidiaries, including NJR Investment, a company which makes and holds energy-related investments, through equity instruments of public companies. NJR Energy Corporation (NJR Energy), a company that invests in energy-related ventures. NJR Service an unregulated company, which provides shared administrative services, including corporate communications, financial and planning, internal audit, legal, human resources and information technology for NJR and all subsidiaries.
The Company operates within four reportable business segments: Natural Gas Distribution, Clean Energy Ventures, Energy Services and Energy Holdings. The Natural Gas Distribution segment consists of regulated energy and off-system, capacity and storage management operations. The Clean Energy Ventures segment consists of capital investments in renewable energy projects. The Energy Services segment consists of unregulated wholesale energy operations. The Energy Holdings segment consists of investments in the midstream natural gas market, such as natural gas transportation and storage facilities.
Natural Gas Distribution
NJNG provides natural gas service to approximately 500,100 customers. NJNG's service territory is in New Jersey's Monmouth and Ocean counties and parts of Burlington, Morris, Middlesex and Sussex counties. It encompasses 1,516 sq! uare mile! s, covering 105 municipalities with an population of 1.4 million people. During the fiscal year ended September 30, 2012 (fiscal 2012), NJNG added 6,704 new customers and added natural gas heat and other services to another 539 existing customers. During fiscal 2012, NJNG's gas supply portfolio consists of long-term (over seven months), winter-term (November through March) and short-term (seven months or less) contracts. During fiscal 2012 , NJNG purchased gas from approximately one hundred suppliers under contracts ranging from one day to one year and purchased over 10% of its natural gas from two suppliers. NJNG maintains agreements for firm transportation and storage capacity with several interstate pipeline companies. NJNG receives natural gas at eight citygate stations located in Middlesex, Morris and Passaic counties in New Jersey.
The pipeline companies, which provide firm contract transportation service for NJNG and supply the above pipelines are ANR Pipeline Company (ANR), Iroquois Gas Transmission L.P., Tennessee Gas Pipeline Company, Dominion Transmission Corporation (Dominion) and Columbia Gulf Transmission Company. In addition, NJNG has storage and related transportation contracts, which provide additional maximum daily deliverability to NJNG's citygate stations of 102,941 decatherm from storage fields in its Northeast market area.
Clean Energy Ventures
NJRCEV is an unregulated company, which invests, owns and operates renewable energy projects located in the State of New Jersey and owns an interest in an on-shore wind project developer. NJRCEV invests in, owns and operates residential and commercial solar installations in the State of New Jersey. As of September 30, 2012 , NJRCEV has placed a total of 35.9 megawatts of solar assets into service, including a combination of residential and commercial rooftop and ground mount solar systems.
Energy Services
NJRES provides unregulated wholesale energy services and engages in! the busi! ness of optimizing natural gas storage and transportation assets. The rights to these assets are acquired in anticipation of delivering natural gas or performing asset management activities for the Company's customers or in conjunction with identifying arbitrage opportunities that exist in the marketplace. These activities are conducted in the market areas, which include states from the Gulf Coast and Mid-Continent regions to the Appalachian and Northeast regions, the West Coast and Canada.
NJRES has developed a portfolio of natural gas storage and transportation capacity in the Gulf Coast, Mid-Continent, Appalachian and Northeast regions, the West Coast and Canada. NJRES also participates in park-and-loan transactions with pipeline and storage counterparties, where NJRES will park (store) natural gas to be redelivered to NJRES at a later date or borrow to be returned to the pipeline or storage field at a later date. NJRES has built a portfolio of customers, including local distribution companies, industrial companies, electric generators, retail aggregators, natural gas producers and other wholesale marketing companies.
Energy Holdings
Energy Holdings include investments in natural gas transportation and storage assets and is consisted of NJNR Pipeline, which consists of its 5.53% equity investment in Iroquois Gas Transmission System, which is a 412 -mile natural gas pipeline from the New York-Canadian border to Long Island, New York, and NJR Steckman Ridge Storage Company, which holds the Company's 50% equity investment in Steckman Ridge. Steckman Ridge is a partnership, jointly owned and controlled by subsidiaries of the Company and subsidiaries of Spectra Energy Corporation, which built, owns and operates a 17.7 billion cubic feet natural gas storage facility in western Pennsylvania.
Other Business Operations
Retail and Other operations consist of the unregulated affiliates, including NJRHS, which provides HVAC service, sales and ! installat! ion of appliances to approximately 134,900 customers, as well as installation of solar equipment, and CR&R, which holds and develops commercial real estate. As of September 30, 2012 , CR&R's real estate portfolio consisted of 27 acres of undeveloped land in Monmouth County, 52 acres of undeveloped land in Atlantic County, and a 56,400 -square-foot office building on five acres of land in Monmouth County. NJR Investment invests in and holds certain energy-related investments, through equity instruments of public companies. NJR Energy invests in energy-related ventures. NJR Service provides shared administrative and financial services to the Company and all its subsidiaries.
Advisors' Opinion:- [By The Part-time Investor]
New Jersey Resources (NJR)
Since I wanted to increase the yield of my portfolio, I decided to look at just the REITs and Utilities for my new purchases, and not the "regular" stocks. I avoided MLPs due to the tax issues (which will be discussed later). I already own OHI, DLR, O, AVA and D. So I decided to buy DX, the only REIT I didn't already own, and WEC, the utility which had the highest, and most consistent dividend growth rate.
Top 10 Up And Coming Companies To Invest In 2014: Regal Beloit Corporation(RBC)
Regal Beloit Corporation, together with its subsidiaries, manufactures and sells electric motors and controls, electric generators and controls, and mechanical motion control products primarily in the United States and Asia. The company operates in two segments, Electrical and Mechanical. The Electrical segment manufactures and markets AC and DC commercial, industrial, and commercial refrigeration electric motors and blowers, as well as heating, ventilation, and air conditioning (HVAC) electric motors and blowers. It also provides precision servo motors, electric generators, automatic transfer switches and paralleling switchgear, and control electric power generation equipment; AC and DC variable speed drives and controllers, and other accessories for industrial and commercial applications; and capacitors for use in HVAC systems, high intensity lighting, and other applications. The Mechanical segment manufactures and markets a range of mechanical motion control products, i ncluding worm gears, bevel gears, helical gears, and concentric shaft gearboxes; marine transmissions; after-market automotive transmissions, and ring and pinions; custom gearing; gearmotors; electrical connecting devices; and manual valve actuators, which are used in oil and gas, water distribution and treatment, and chemical processing applications. The company sells its products to original equipment manufacturers, distributors, and end users through its direct sales people and manufacturer?s representative organizations. Regal Beloit Corporation was founded in 1955 and is based in Beloit, Wisconsin.
Advisors' Opinion:- [By Rich Duprey]
Electric motor manufacturer�Regal Beloit� (NYSE: RBC ) �will pay a�regular quarterly dividend�of $0.30 on July 12 to the holders of record at the close of business on June 28.
- [By Seth Jayson]
Calling all cash flows
When you are trying to buy the market's best stocks, it's worth checking up on your companies' free cash flow once a quarter or so, to see whether it bears any relationship to the net income in the headlines. That's what we do with this series. Today, we're checking in on Regal Beloit (NYSE: RBC ) , whose recent revenue and earnings are plotted below. - [By Rich Duprey]
Electric-motor maker�Regal Beloit (NYSE: RBC ) announced on Friday its third-quarter dividend of $0.20 per share, the same rate it paid last quarter after raising the payout 5% from $0.19 per share.
Top 10 Up And Coming Companies To Invest In 2014: Insys Therapeutics Inc (INSY)
Insys Therapeutics, Inc., incorporated on June 15, 1990, is a pharmaceutical company that develops and seeks to commercialize pharmaceutical products that target the unmet needs of cancer patients, with an initial focus on cancer-supportive care. The Company�� pharmaceuticals portfolio consists of one approved product and a number of product candidates targeting cancer-supportive care and cancer therapy. The Company�� product candidate includes Subsys, Dronabinol SG Capsule, Dronabinol RT Capsule, Dronabinol Oral Solution, Dronabinol Inhalation Device, and Dronabinol IV Solution. The Company is also developing cancer therapeutics, which is LEP-ETU, a formulation of paclitaxel, the active ingredient in the cancer drugs Taxol and Abraxane. On August 19, 2011, the Food & Drug Administration (FDA) approved its Dronabinol SG Capsule product, a generic equivalent to Marinol, for the treatment of chemotherapy induced nausea and vomiting (CINV), and anorexia associated with weight loss in patients with acquired immune deficiency syndrome (AIDS).
Subsys
The Company's Subsys is a single-use product that delivers fentanyl, an opioid analgesic, in seconds for transmucosal absorption underneath the tongue. Subsys is a transmucosal product to show pain relief when measuring the sum of pain intensity difference at five minutes in a Phase 3 breakthrough cancer pain (BTCP) clinical trial using fentanyl.
Dronabinol Product Family
The Company has an approved dronabinol product and is developing several dronabinol product candidates for the treatment of CINV and appetite stimulation in patients with AIDS, as well as other indications where dronabinol could have potential therapeutic benefits. Dronabinol, the active ingredient in Marinol, is a synthetic cannabinoid whose chemical name is delta-9-tetrahydrocannabinol (THC). Its portfolio consists of its Dronabinol SG Capsule product and Dronabinol RT Capsule product candidate, which are intended to be generic equi! valents to Marinol, in addition to three formulations, including Dronabinol Oral Solution. Dronabinol SG Capsule is a dronabinol soft gelatin capsule intended to be a generic equivalent to Marinol. Dronabinol RT Capsule is a dronabinol soft gel capsule that is stable at room temperature. Dronabinol Oral Solution is a ynthetic THC in an oral liquid formulation.
Cancer Therapeutics
In addition to its cancer-supportive care products, the Company intends to develop cancer therapeutics targeting limitations of existing commercial products. LEP-ETU, it advanced cancer therapeutic, is a NeoLipid liposomal, or microscopic membrane-like structure created from lipids, formulation that incorporates paclitaxel. LEP-ETU completed a Phase 2 clinical trial of 70 patients with metastatic breast cancer.
The Company competes with Cephalon, Inc., BioDelivery Sciences International, Inc., ProStrakan Group plc, Nycomed International Management GmbH, Archimedes Pharma Ltd., TEVA Pharmaceuticals USA, Watson Pharmaceuticals, Inc., AcelRx Pharmaceuticals, Inc., Akela Pharma Inc., Abbott Laboratories, Pharmaceutical International, Inc., Par Pharmaceutical Companies Inc., sanofi-aventis, Eisai Inc., Helsinn Group, Roche Holding AG, Par Pharmaceutical Companies Inc., GlaxoSmithKline plc, ProStrakan Group plc, Merck & Co, GW Pharmaceutical, A.P. Pharma, Inc., Aphios Corp., Roche Holding, Tesaro, Inc., Cornerstone Pharmaceutical, Inc., Bristol-Myers Squibb, Celgene Corporation, Laboratories, Amgen Inc., AstraZeneca PLC., Bayer AG, Biogen Idec Inc., Eisai Co., Ltd., F. Hoffmann- LaRoche Ltd., Johnson and Johnson, Merck and Co., Inc., Novartis AG, Onyx Pharmaceuticals Inc., Pfizer Inc., and Takeda Pharmaceutical Co. Ltd.
Advisors' Opinion:- [By Jake L'Ecuyer]
INSYS Therapeutics (NASDAQ: INSY) was also down, falling 15.14 percent to $27.73 after news broke that a doctor had fraudulently prescribed its drug Subsys.
- [By Chris Preston]
INSYS Therapeutics (INSY) is one recent IPO that jumps out. The Arizona-based pharmaceutical company markets a synthetic marijuana drug to treat cancer pain. It went public in May at $8 per share. It opened at over $46 per share.
Top 10 Up And Coming Companies To Invest In 2014: ()
DGS Minerals Inc., an exploration stage company, engages in the acquisition, exploration, and development of mineral properties in Canada. It primarily explores for gold. It holds an option to acquire a 100% interest in the Gordon Creek property, an epithermal precious metals project consisting of 4 mineral claims with an area of 2,066.08 hectares and is located northeast of Merritt, British Columbia. The company was formerly known as Challenger Development Corp. and changed its name to DGS Minerals Inc in April 2013. DGS Minerals Inc. was incorporated in 1990 and is based in Vancouver, Canada.
Advisors' Opinion:- [By Holly LaFon]
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Top 10 Up And Coming Companies To Invest In 2014: Dolan Co (DM)
The Dolan Company, incorporated in March 2003, is a provider of necessary professional services and business information to legal, financial and real estate sectors in the United States. The Company operates through two operating divisions: its Professional Services Division and its Business Information Division. Its Professional Services Division consists of two segments: mortgage default processing services and litigation support services. Its Business Information Division produces legal publications, business journals, court and commercial media, other online information products and services, and operates Websites and produces events for targeted professional audiences in 21 geographic markets across the United States. Its information is delivered through a variety of methods, including approximately 60 print publications and 80 Websites. The Company also operates specialized information services covering legislative and regulatory activities and providing transcription, media monitoring and translation services. On July 25, 2011, it acquired substantially all of the assets of ACT Litigation Services, Inc. (ACT). In July 2013, the Company sold the assets of its NDeX South business to the law firm affiliates of that business.
Professional Services
The Company�� Professional Services Division consists of two operating segments: mortgage default processing services and litigation support services. Its mortgage default processing services segment consists of the operations of NDeX. Its litigation support services segment consists of the operations of DiscoverReady, its discovery management and document review services business, and Counsel Press, its appellate services business. The Company provides these support services to the legal profession. In addition, NDeX also provides its services directly to mortgage lenders and loan servicers on California foreclosure files. One of the litigation support services it provides is discovery management and document review services, ! including certain technology services related to processing and hosting the data. Discovery is the process by which parties use the legal system to obtain relevant information, primarily in litigation, regulatory, and governmental investigation matters. Some United States companies with in-house legal departments choose to perform or manage some portions of the discovery process in-house, rather than outsourcing them.
The Company provides appellate services to lawyers in connection with both state and federal appeals. It performs more state appellate work, as state appellate case volume generally is larger than federal case volume. There are typically about 300,000 state appeals filed each year, compared to approximately 58,000 federal appeals filed per year, according to information available to the Company from the Administrative Office of the United States Courts and the National Center for State Courts. NDeX also provides real estate title services to the Barrett Law Firm and provides loan modification and loss mitigation support on mortgage default files to its customers. During the year ended December 31, 2011, it received approximately 317,200 mortgage default case files for processing from its customers.
In 2011, its mortgage default processing services segment accounted for 46% of its total revenues and 63% of its Professional Services Division�� total revenues. The Company�� litigation support services professionals at Counsel Press provide clients with consulting services, including procedural and technical advice and support with respect to the United States state and federal appellate processes. During 2011, its litigation support services segment accounted for 27% of its total revenues and 37% of its Professional Services Division�� total revenues. In addition to its appellate services, Counsel Press provides additional tracking and professional services to its clients.
Business Information
The Company provides business informatio! n product! s to companies and professionals in the legal, financial, real estate and governmental affairs sectors primarily through print and online business journals and court and commercial newspapers, as well as other electronic media offerings. Its business journals generally rely on display and classified advertising as a significant source of revenue and provide content that is relevant to the business communities they target. Its court and commercial newspapers generally rely on public notices as their primary source of revenue and offer information to the legal communities they target. All of its business journals and court and commercial newspapers also generate circulation revenue to supplement their advertising and public notice revenue base. There were more than 230 local business journals and more than 350 court and commercial newspapers nationwide, which generated approximately $2 billion in revenues in 2011.
The Company sells packaged print and online advertising products to advertisers that desire to reach readers through different media. Dolan Media Newswires, its Internet-based, subscription newswire, is available at www.dolanmedianewswires.com for news professionals and represents the work of its journalists and contributors. It also operates online, subscription-based legislative information services that are used by lobbyists, associations, corporations, unions, government affairs professionals, state agencies and the media in Arizona, Minnesota and Oklahoma. Through DataStream, it offers customized access to legislative databases, which provide state and federal legislative and regulatory information. Through Federal News, the Company offers transcription services.
The Company provides commercial printing services and sells database information through royalty or licensing fee arrangements. During2011, its subscription-based and other revenues accounted for 8% of its total revenues and 28% of its Business Information Division�� total revenues. The Company prints se! ven of it! s business information publications at one of its three printing facilities located in Baltimore, Minneapolis and Oklahoma City.
Advisors' Opinion:- [By Roberto Pedone]
Another under-$10 stock that looks poised for a sharp move higher is Dolan (DM), a provider of necessary business information and professional services to the legal, financial and real estate sectors in the U.S. This stock has been hammered by the sellers so far in 2013, with shares off huge by 80%.
If you take a look at the chart for Dolan Company, you'll notice that this stock has been downtrending badly over the last two months, with shares plunging lower from its high of $3 a share to its recent low of 66 cents per share. During that downtrend, shares of DM have been consistently making lower highs and lower lows, which is bearish technical price action. That move has now pushed shares of DM into oversold territory, since its current relative strength index reading is 20. Oversold can always get more oversold, but it's also an area where a stock can make a powerful bounce higher from.
Market players should now look for long-biased trades in DM if it manages to break out above Thursday's high of 77 cents per share and then above some more near-term overhead resistance at 80 cents per share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 321,823 shares. If that breakout hits soon, then DM will set up for a possible powerful bounce higher that could easily take this stock back above $1 to $1.20 a share.
Traders can look to buy DM off weakness to anticipate that breakout and simply use a stop that sits right around some key near-term support levels at 71 cents to 66 cents per share. One can also buy DM off strength once it starts to clear those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.
Top 10 Up And Coming Companies To Invest In 2014: Points International Ltd (PCOM)
Points International Ltd. provides a range of e-commerce and technology services to loyalty program operators using. These services consist of a range of e-commerce services (referred as its Loyalty Currency Services) that enable the sale of loyalty currencies (such as frequent flyer miles, hotel points and credit card points), both retail and wholesale. The Company also offers a reward management Website referred to as Points.com. The majority of the Company�� loyalty program partners operate in the United States. It also has a European customer base. It has three wholly owned direct subsidiaries: Points.com Inc., Points International (UK) Limited, and Points International (U.S.) Ltd. The Company�� services are generally delivered through Web-enabled e-commerce solutions. Points.com offers members of multiple loyalty programs the ability to track and manage their loyalty currencies. Advisors' Opinion:- [By Hank Coleman]
Anna Subbotina/Shutterstock You may not be fully aware of it, but you're probably sitting on your own personal treasure hoard: a stash of airline miles, hotel points or reward points you've earned through your credit cards. According to statistics compiled by Points.com and its parent Points International (PCOM), a company specializing in helping consumers trade, exchange and redeem reward points, the average American is hoarding more than 61,000 reward points through various programs. Americans have more than 2.65 billion loyalty memberships -- almost 10 per person. This would be fine if we were spending those points -- but we're not. According to Points.com, only 16 percent of us redeem the points that we earn each year. Why do we love reward points? Is there a danger in hoarding them? What should we do with our points as our balances continue to grow? Why Do We Love Reward Points So Much? Getting something for free is a big allure of reward points and loyalty programs. I love that my airline-branded credit card allows me to check a bag for free. Companies view reward programs as marketing by gamification. If businesses can make patronizing them into a game for their customers, they'll be more likely to do what it takes to advance to the next level. And of course, these programs inspire brand loyalty. I'm a huge fan of Fitbit. I'm always striving for the next badge or level with my fitness goals through the site and its devices. I'm also addicted to checking in to the places that I frequent on Foursquare. It drives me crazy when someone ousts me as the mayor of one of my favorite haunts. Gamification is going on with reward points themselves. Companies have found that we desperately want to get to the next level of rewards. That's why companies have different colored credit cards and exclusive levels that offer even more freebies to loyal customers -- though usually for a price. And we are dreamers. We dream that our frequent flyer miles and hotel rew
Top 10 Up And Coming Companies To Invest In 2014: Cytomedix Inc (CMXI)
Cytomedix, Inc. (Cytomedix), incorporated in April 29, 1998, is a regenerative therapies company marketing and developing products within the United States and internationally .The Company commercializes cell-based technologies that harness the regenerative capacity of the human body to trigger natural healing. The Company is a commercial operation, and a robust clinical pipeline representing a logical extension of its commercial technologies in the evolving field of regenerative medicine. Cytomedix primarily operates in the United States. Its commercial offerings are centered on its point of care platform technologies for the safe and efficient separation of blood and bone marrow to produce platelet based therapies or cell concentrates.
The Company markets and selsl two distinct platelet rich plasma (PRP) technologies, the AutoloGel System for wound care and the Angel concentrated Platelet Rich Plasma (cPRP) Sytem in orthopedic and cardiovascular markets. Its clinical pipeline includes the ALDH, which are cell-based therapies (Bright Cells). In February 2012, the Company acquired Aldagen, Inc.
The AutoloGel System
The AutoloGel System is a point of care device for the production of a platelet based bioactive therapy derived from a small sample of the patient�� own blood. Using the patient�� own platelets as a therapeutic agent, AutoloGel harnesses the body�� natural healing processes to deliver growth factors, chemokines and cytokines known to promote angiogenesis and to regulate cell growth and the formation of new tissue.
Angel Product Line
The Angel concentrated Platelet Rich Plasma (cPRP) System is a multi-functional cell separation device which produces concentrated platelet rich plasma for use in the operating room and clinic and is used in a range of orthopedic and cardiovascular indications. Similar to the AutoloGel System, the Angel System is a point of care device for the production of a concentrated, aseptic platelet! -based bioactive therapy derived from a small sample of the patient�� own blood. The resulting cPRP is applied at the site of injury to promote healing. The Angel product line also includes ancillary products such as phlebotomy and applicator supplies and activAT. activAT is designed to produce autologous thrombin serum from platelet poor plasma and is sold exclusively in Europe and Canada, where it provides a safe alternative to bovine-derived products.
ALDHbr Cell Technology and Development Pipeline
The ALDHbr (Bright Cell) technology is an approach to cell-based regenerative medicine and a logical extension of its commercial technologies in the evolving regenerative medicine market, with potential clinical indications in markets with unmet medical needs such as peripheral arterial disease and ischemic stroke. The Bright Cell technology is in that it utilizes an intracellular enzyme marker to facilitate fractionation of essential regenerative cells from a patient�� bone marrow. The bone marrow fractionation process identifies and isolates active stem and progenitor cells expressing high levels of the enzyme aldehyde dehydrogenase, or ALDH, which is a key enzyme involved in the regulation of gene activities associated with cell proliferation and differentiation.
The Company�� lead product candidate, ALD-401, is an autologous preparation of Bright Cells for the post-acute treatment of ischemic stroke. ALD-401 is being evaluated in the RECOVER-Stroke clinical study, an ongoing 100-patient, double-blind, placebo-controlled Phase 2 study in patients with unilateral, cerebral ischemic stroke with an NIH stroke scale score of less than 22. An additional product candidate, ALD-301, is in clinical development for peripheral arterial disease (PAD), a condition causing reduced flow of blood and oxygen to muscles in the leg. It has completed a Phase 1/2 study of autologous ALD-301 in critical limb ischemia (CLI), a late stage condition caused by PAD. The Phase 2 PACE! (Patient! s with Intermittent Claudication Injected with ALDH Bright Cells) study is an 80 patient, double-blind, placebo-controlled clinical trial intended to demonstrate the safety and efficacy of ALD-301 (Bright Cells) in patients diagnosed with IC.
The Company competes with Harvest Technologies (a subsidiary of Terumo), Biomet, Arteriocyte, and Arthrex.
Advisors' Opinion:- [By James E. Brumley]
To give credit where it's due, Cytomedix, Inc. (OTCBB:CMXI) and Baxter International Inc. (NYSE:BAX) have both helped shape the landscape of the hemostasis (bleeding control) market with their products, AutoloGel and TISSELL, respectively. Arch Therapeutics Inc. (OTCBB:ARTH) has proverbially taken their concepts "up a notch", however, and its direct solution to a problem that CMXI and BAX can't quite solve may make ARTH the hottest trading candidate in the hemostasis space.
- [By Bryan Murphy]
When traders think of post-surgical wound management stocks, they may first think of names like Cytomedix, Inc. (OTCBB:CMXI) or Alliqua Inc. (OTCMKTS:ALQA). And well they should. Both companies have something of a history in the arena. ALQA is the purveyor of SilverSeal and Hydress antibiotic bandages, while CMXI is the developer of the AutoloGel system, which induces an affected patient's on body to do what it's supposed to do if there's a wound that won't heal. Cytomedix also makes the Angel platelet-rich plasma (PRP) delivery system. There's a relatively new name to add to the list of game-changing stocks in wound-management industry, however.... Arch Therapeutics Inc. (OTCBB:ARTH). The company is developing - well, has developed - a product called AC5 that nips post-surgical bleeding in the bud, largely negating the need for other post-surgical bleeding-control measures.
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